cAMP modulates an S-type K+ channel coupled to GABAB receptors in mammalian respiratory neurons
PG Wagner, MS Dekin - Neuroreport, 1997 - journals.lww.com
PREMOTOR respiratory neurons from neonatal rats express a Ba 2+-insensitive outward
rectifying K+ channel (K OR) which is activated by γ-aminobutyric acid acting at its β
receptor. The biophysical properties of K OR are similar to those described for the S-channel
(KS) which underlies simple forms of non-associative learning in the marine mollusc Aplysia.
We show here that K OR, like the S-channel, is inhibited by cAMP. In addition, we
demonstrate that this inhibition is due to a change in closed time kinetics. Our data suggests …
rectifying K+ channel (K OR) which is activated by γ-aminobutyric acid acting at its β
receptor. The biophysical properties of K OR are similar to those described for the S-channel
(KS) which underlies simple forms of non-associative learning in the marine mollusc Aplysia.
We show here that K OR, like the S-channel, is inhibited by cAMP. In addition, we
demonstrate that this inhibition is due to a change in closed time kinetics. Our data suggests …
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